Selfish spermatogonia

Selfish metabolism

2008 Wiley Periodicals, Inc. Complexity 7: 7–13, 2008 E volutionary biology has traditionally made much of the concept of selfishness. Charles Darwin reduced adaptation (and to a less satisfying degree, speciation) to the heritable variation and competition among individuals. As understanding of the genetic control of heredity and morphogenesis has become more sophisticated, Richard Dawkins has...

Selfish Knapsack

We consider a selfish variant of the knapsack problem. In our version, the items are owned by agents, and each agent can misrepresent the set of items she owns—either by avoiding reporting some of them (understating), or by reporting additional ones that do not exist (overstating). Each agent’s objective is to maximize, within the items chosen for inclusion in the knapsack, the total valuation ...

Spermatogonia: stem cells with a great perspective.

Interest in spermatogonia has grown in recent years as a result of exciting developments in stem cell research in general and the development of new research tools allowing the isolation, culture and transplantation of these cells. This review focuses on the methodological breakthroughs and highlights the recent findings that have substantially increased understanding of spermatogonial physiolo...

Spermatogonia differentiation requires retinoic acid receptor γ.

Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three nuclear receptor isotypes, RA receptor (RAR)α (RARA), RARβ, and RARγ (RARG). Here, we show that 1) RARG is expressed by A aligned (A(al)) spermatogonia, as well as during the transition from A(al) to A(1) spermatogonia, which is known to ...

The Selfish Brain Theory